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Research paper on genetic diseases

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The VGL is actively engaged in research endeavors to improve breeding programs, animal health, and conservation efforts of a wide range of species including domestic species, natural wildlife, and colony-maintained populations. Genes, environment, and their interaction play critical roles in animal health and disease, and our scientists are continuously breaking new ground and deepening our understanding of the animal world through advancements in this exciting field. Genetics research not only furthers understanding of which animals are at risk for particular diseases, but ongoing discoveries can also lead to the development of diagnostic tests and potential therapies for treatment, resulting in earlier disease intervention and improved health outcomes. For decades, the VGL has been actively involved in research that contributed to the understanding of the horse, dog, and cat genomes, well before sequencing genomes was possible. Research at the VGL laid the groundwork for mapping of the horse genome that later was essential in developing the first horse reference genome sequence. The sequencing of many animal genomes has helped to develop powerful tools with which to investigate inherited traits and diseases.
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Huntington's Disease: Hope Through Research

Research paper on genetic diseases
Research paper on genetic diseases
Research paper on genetic diseases
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Genetics Basics | CDC

Description The name progeria means "early age". It is the most well-known form of the premature aging diseases that include Werner syndrome, Cockayne syndrome and Rothmund-Thomson syndrome. Although born looking healthy, infants with progeria quickly start to display many characteristics of accelerated aging at around months of age Gilbert, Demographics Progeria has a reported incidence of about 1 in million newborns. It affects both sexes and all races equally. Causes and symptoms Progeria syndrome is caused by a mutation in a gene called LMNA, which produces the proteins lamin A and lamin C, structural proteins that are essential components of the nuclear envelope that surrounds the nucleus of cells.
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A genetic assessment of the English bulldog

There is no question that the rapid advance in genetic technology is changing our viewpoint on medical practice, which is dramatically improving the diagnosis, prognosis, and therapy of human genetic disease. In particular, the next-generation sequencing NGS technologies, such as exome sequencing and whole-genome sequencing, and gene editing technology have been applied to several areas, such as genomes, transcriptomes, and epigenomes, and have transformed the genetic research of human diseases. As a powerful and cost-effective discovery and diagnostic tool, exome sequencing was widely used in detecting disease-associated variants underlying genetic disease and developed genetic research such as personalized medicine and personal genomics. Through rigorous peer review, this special issue includes high-quality papers.
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In a research paper published in Nature Aging , the team reports using a novel approach to provide the first data-driven classification of multiple diseases obtained using human genetic and medical data freely available from the UK Biobank. Understanding the molecular links between the aging process and age-related diseases could allow them to be targeted with drugs to improve late-life health. The researchers grouped these diseases based on their age of onset to define the relationship between disease incidence and age. This revealed genetic links between diseases with the same onset profile, suggesting that they may share a common cause.
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