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Histoplasma capsulatum in new england a case study

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A 61 year old African American male presents to the emergency department with complaints of a productive cough, dyspnea and altered mental status. His past medical history is significant for HIV and currently he is non-compliant with his anti-retroviral medications. He lives in a group home and they report decreased oral intake for several days but he denies fever, chills, chest pain or abdominal pain. He is a tobacco smoker and admits to previous illicit drug use. On physical exam, he is lethargic and respiratory auscultation reveals coarse lung sounds, bilaterally.
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Human Immunodeficiency Virus (HIV) Infection

Histoplasma capsulatum in new england a case study
Histoplasma capsulatum in new england a case study
Histoplasma capsulatum in new england a case study
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Learning Lab | NEJM Resident

Histoplasma capsulatum is a species of dimorphic fungus. Its sexual form is called Ajellomyces capsulatus. It can cause pulmonary and disseminated histoplasmosis. It was discovered by Samuel Taylor Darling in It is potentially sexual, and its sexual state, Ajellomyces capsulatus , can readily be produced in culture, though it has not been directly observed in nature.
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Fungal culture

Pulmonary histoplasmosis may be misdiagnosed as tuberculosis TB. In the last six decades — , cases of histoplasmosis have been reported. West Africa had the highest number of recorded cases with ; the majority cases were caused by Histoplasma capsulatum var. From the Southern African region, cases have been reported, and the majority were caused by H. Most cases of Hcd presented as localised lesions in immunocompetent persons; however, it was disseminated in AIDS patients.
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Sarcoidosis involves abnormal collections of inflammatory cells granulomas which may form as nodules in multiple organs. We present a year-old male with sarcoidosis who was admitted for respiratory distress. Fibrosing mediastinitis was seen in the chest computograph.
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