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Bovine tuberculosis thesis

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Mycobacterium bovis M. It is related to Mycobacterium tuberculosis , the bacterium which causes tuberculosis in humans. The bacteria are curved or straight rods. They sometimes form filaments, which fragment into bacilli or cocci once disturbed.

University of Minnesota/Accligen Research Fellowship 2021 for African Women Researchers.

Bovine tuberculosis thesis
Bovine tuberculosis thesis
Bovine tuberculosis thesis

A political ecology of bovine tuberculosis eradication in Northern Ireland - Durham e-Theses

Updated information on data from newly infected cattle herds biosecurity, cattle movement to and from affected herds, cattle feeding practices, cattle housing, and wildlife access to livestock and livestock feed and additional retrospective data collection was used to refine the existing predictive model, which is undergoing testing. JD did not affect the result of the caudal fold test CFT , as all sensitized cattle showed a positive reaction, but did adversely affect the results of the whole blood gamma interferon test in some cattle. Project 3: To identify altered gene expression patterns in cattle that are false positive on current TB tests as potential diagnostic targets for TB detection, whole blood was collected from 60 lesion negative cattle suspect for TB on the CFT and the comparative cervical test CCT or the whole blood gamma interferon test, and 19 microarray analyses have been completed for RNA samples from blood pre-stimulated with M. Altered gene expression of 5-fold or greater was seen in each group: 10 up- and 2 down-regulated genes from CFT reactors, up- and 5 down-regulated genes from double reactors, and 12 up- and 5 down-regulated genes from TB positives. No genes demonstrating altered expression levels were shared among or between these groups of cattle. The 0-hr microarrays showed only 4 genes with altered expression and none showed altered levels that were greater than 5-fold above or below control values. BCG vaccinates maintained activity and body weight, and only 2 of 12 mice were sacrificed 7 weeks post challenge.

Bovine tuberculosis: molecular epidemiology and implications in Public and Animal Health

Bovine tuberculosis bTB is an infectious disease with a complex epidemiology at the human-animal-environment interface which, despite the application of extensive control measures, is still prevalent in livestock and wildlife in several regions of Spain. The disease, caused by Mycobacterium bovis and to a lesser extent M. Disease eradication at the herd level is challenging due to several factors including the limitations in the sensitivity of available diagnostic techniques, the risk of introduction of undetected infected animals, the proximity to positive farms, and the contact with infected wildlife reservoirs. This thesis is based on the application of different analytic tools such as social network analysis, epidemiological models and whole genome sequencing WGS to quantify the relative importance of risk factors impairing disease control in Spain using a multidisciplinary approach. Chapter 1 includes the characterization of the cattle movement network in Castilla y Leon, a high bTB prevalence area in Spain, and the assessment of the possible role of between-farm movements on the observed pattern of bTB breakdowns between and in the region.
Bovine Tuberculosis is an infectious disease caused by individual pathogenic acid-fast organisms of the genus Mycobacterium. It is usually characterized by the progressive development of nodular granulomas known as tubercles in any of the organs in most species. Although commonly defined as a chronic, wasting disease, TB occasionally assumes an acute, rapidly progressive course.
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